Eicosanoids are products of arachidonic acid (AA), an essential fatty acid. They include prostaglandins (PGs), prostacyclin (PGI2), thromboxanes (TXs), leuko-trienes (LTs) and hydroxy fatty acids. AA is derived enzymatically from membrane phospholipids and to a lesser extent the diet. Eicosanoids self-regulate every cell,including those synthesizing serotonin,...

Prostaglandins are nature’s universal signalers, self-regulating every physiological function, and defined as “a generalized physiological control mechanism”. They are minute, ephemeral, and powerful, and extraordinarily sensitive to all forms of stress. whether mechanical, physical, chemical, biological, or interpersonal. When enzymes increase prostaglandin production...

Stimulating defective immune function to perform efficiently is a desirable approach to defeating pathogens. Such stimulation is represented as unavailable, while in truth the immunostimulating properties of lithium and antidepressants were documented many years ago.[1-4] A therapeutic claim is reinforced when the mechanism is known. Prostaglandins, when produced excessively,...

The preimplantation human conceptus would be destroyed by an attack by the mother’s immune system, as half of its contents come from its father. Instead, the conceptus temporarily increases its production of prostaglandin E2, which, when elevated, becomes a powerful immunosuppressant, to ward off the attack. In the absence of this mechanism, reproduction would be impossible....

“AS THE births of living creatures, at first are ill-shapen, so are all innovations, which are the births of time. Yet notwithstanding, as those that first bring honor into their family, are commonly more worthy than most that succeed, so the first precedent (if it be good) is seldom attained by imitation. For ill, to man’s nature, as it stands perverted, hath...