Hope For Resistant Bacteria

“AS THE births of living creatures, at first are ill-shapen, so are all innovations, which are the births of time. Yet notwithstanding, as those that first bring honor into their family, are commonly more worthy than most that succeed, so the first precedent (if it be good) is seldom attained by imitation. For ill, to man’s nature, as it stands perverted, hath a natural motion, strongest in continuance; but good, as a forced motion, strongest at first. Surely every medicine is an innovation; and he that will not apply new remedies must expect new evils; for time is the greatest innovator; and if time of course alters things to the worse, and wisdom and counsel shall not alter them to the better, what shall be the end?”

 

Francis Bacon

 

Francis Bacon was the father of modern science. This passage is the prelude to his essay on innovation. In his day, William Shakespeare was Bacon’s only intellectual equal. In addition to writing about the perils of corrupting innovation, Bacon also noted, that if one wishes to outperform one’s peers in science or medical science, one must practice more humanity than they do, humanity meaning ethics and charity, or altruism.

 

Another of his accomplishments was originating the concept of inductive reasoning, as compared to deductive. Ironically, an inductive hypothesis finished him off. Bacon was driving around London in a carriage following a snowstorm. He formulated the hypothesis that snow might have antiseptic properties, and left the carriage to gather it. The following day, he developed an upper respiratory tract infection, and passed away.

 

Stimulating immune function to perform efficiently is the logical approach to defeating pathogens. Such stimulation is propagandized as unavailable, when Louis Shenkman, M.D  documented the potent immunostimulating and antibacterial properties of lithium in 1980, and I in 1981 the first of nine review articles on the remarkable immunostimulating and antimicrobial properties of lithium and antidepressants.

 

My “Stimulating immune function to kill viruses” was recently released (Amazon), and applies also to bacteria, parasites, and fungi. A therapeutic claim is reinforced when the mechanism is known.

 

In this case, minute molecules known as prostaglandins, when produced excessively, depress every component of immune function, and induce microbial replication. In the early nineteen seventies, my late colleague David Horrobin and others showed that antidepressants and lithium inhibit prostaglandins.

 

Lithium has immunostimulating, antiviral and antibacterial properties, antidepressants immunostimulating, antiviral, antibacterial, antiparasite, and fungicidal properties.

A recent study has shown that antidepressants frequently reduce HIV viral load to undetectable. With the threats posed by resistant T.B, HIV, resistant bacteria, and the emerging resistance of the malaria parasite to artemisin, the availability of immunostimulation becomes all the more crucial.

 

In a review published in 1983, I proposed that to stimulate immune function, an agent must have mood elevating properties. Over the past quarter of a century, I appealed to innumerable individuals or institutions to support the advance, none of which obliged. Immunostimulation was available as early as 1980, the consequences of its suppression a catastrophe.

 

Innovations for infectious, cardiovascular, and neurodegenerative disorders, and to some extent autoimmune disorders, have been available for a long time, but suppressed by pandemic medical corruption, with devastating human and economic consequences. Five hundred years ago Bacon uncannily called the disaster.
Defective immune function has many well known causes, but mainstream medical science has ignored the reality that depression and bipolar disorder are invariably accompanied by defective immunity.

 

Logically, if antidepressants and lithium are effective for mood disorders, why wouldn’t they be effective for defective immune function? This is an example of inductive reasoning, which seems to be available only to a minority of scientists. We are ill prepared to cope with a resistant bacteria onslaught, largely because lithium cannot be patented, is ill suited to being a “blockbuster” drug, and because many antidepressants are available as relatively inexpensive generics.

 

Clinical exposure will inform us as to which to favor in combating resistant bacteria.

 

These comments are intended for education only. All treatment decisions should be made with a physician.

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About the Author

Julian Lieb, M.D is a retired Yale medical school professor, and author or coauthor of forty -eight articles and eleven books. With D Jablow Hershman as first author, Dr Lieb coauthored: “Manic Depression and Creativity” and “A Brotherhood of Tyrants: Manic Depression and Absolute Power.” In these volumes, the authors showed that manic- depressive disorder is paradoxical, in gifting society with many creative geniuses, and inflicting many of its great destroyers.

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