TRUTH IS THE DAUGHTER OF TIME (Leonardo da Vinci)…
“Worldwide malaria deaths may be almost twice as high as previously estimated, a study reports.” The research, published in Lancet, suggests 1.24 million people died from malaria in 2010, compared to a World Health Organization estimate for 2010 of 655,000 deaths.
Suppressed Innovations
Salama A Facer CA. Desipramine reversal of chloroquine resistance in wild isolates of Plasmodium falciparum. Lancet.1990 Jan 20; 335(8682):164-165
Henry M, Alibert S, Orlandi-Pradines E et al: Chloroquine resistance reversal agents as promising antimalarial drugs. Curr Drug Targets. 2006 Aug; 7(8): 935-48
Taylor D, Walden JC, Robins AH, Smith PJ. Role of the neurotransmitter reuptake blocking activity of antidepressants in reversing chloroquine resistance in vitro in Plasmodium falciparum. Antimicrob Agents Chemother. 2000 Oct; 44(10): 2689-92
Bitonti AJ, Sjoerdsma A, Cann PP, et al. Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine. Science 1988 Dec 2; 242(4883):1301-3
Basco LK, Le Bras J. Reversal of chloroquine resistance with desipramine in isolates of Plasmodium falciparum from Central and West Africa, Trans R Trop Med Hyg. 1990 Jul-Aug; 84(4):479-81
Brand V, Koka S, Lang C et al: Influence of amitriptyline on eryptosis, parasitemia and survival of Plasmodium berghei-infected mice. Cell Physiol Biochem 2008; 22(5-6):405-12. Epub 2008 Dec 9.
Tor PC, Lee HY, Tan CH. Mefloquine induced mania in a 23 year old Chinese man. Singapore Med J 2006 Jun; 47(6): 549-550*
Brumbaugh M, Price P, Fagan N, Hsieh H.”Psychotic mania associated with mefloquine in a bipolar patient. Southern Med J 2008 May; 101(5); 550-1*
A manic reaction is ironclad evidence that a compound has antidepressant, and thus immunostimulating properties.*
Lamentation:
In 1994, I submitted the “Invisible Antivirals” article to Lancet. Lancet editor Dr Richard Horton, then deputy editor, rejected it as “too long for a hypothesis.”
Think about that. Lancet is infamous for publishing extremely long and clinically worthless articles. It’s akin to saying, ”don’t inject a life-saving substance, if the needle is too long.”
When challenged, a Lancet deputy editor confessed that she suspected that some contributors charge their grants for every word published. How about “hypothesis,” when the article was not a hypothesis but a comprehensive review of the international biomedical literature?
Horton would never have dreamed, that in 2012 the skullduggery would make its way to a freedom of speech blog. Turning to the World Health Organization, it too has repeatedly suppressed the availability of immunostimulation. And why not, everyone else has. Scroll through lay and medical media, and the output on the internet, for any such reference.
Article 19 was written to protect society from such atrocities as occurred during the Second World War. It may yet save the day, but only if many aware of the debacle complies with it. As Francis Bacon noted, “Justice will not support us, if we don’t support justice.”
Additional Reading:
Lieb J. “Immunopotentiation and inhibition of herpes virus activation during therapy with lithium carbonate. Med Hypoth 1981; 7:885-890
Lieb J. “Remission of herpes virus infection and immunopotentiation with lithium carbonate: Inhibition of prostaglandin E1 synthesis by lithium may explain its antiviral, immunopotentiating, and anti-manic properties.” Proceedings of the Third World Congress of Biological Psychiatry, Stockholm. Biol Psych Perris C, Struwe G, Jansson B. (eds.) 1981 695-698
Horrobin D, Lieb J. “A biochemical basis for the actions of lithium on behavior and on immunity: relapsing and remitting disorders of inflammation and immunity such as multiple sclerosis or recurrent herpes as manic-depression of the immune system.” Med Hypoth 1981; 7:891-905
Lieb J. “Remission of rheumatoid arthritis and other disorders of immunity in patients taking monoamine oxidase inhibitors.” Int J Immunopharmac 1983; 5(4): 353-357
Lieb J. “Lithium and immune function.” Med Hypoth 1987; 23:73-93
Lieb J. “Invisible antivirals.” Int J Immunopharm 1994; 16:1, 1-5
Lieb, J. “Lithium and antidepressants: inhibiting eicosanoids, stimulating immunity, and defeating microorganisms.” Medical Hypotheses (2002) 59(4), 429-432
Lieb, J. “The immunostimulating and antimicrobial properties of lithium and antidepressants.” Journal of Infection (2004) 49(2) 88-93
Lieb, J “Lithium and antidepressants: Stimulating immune function and preventing and reversing infection.” Medical Hypotheses (2007) 69, 8-11
Lieb, J.”Stimulating immune function to kill viruses.” (2009) Amazon.
Lieb, J.”Stimulating immune function to defeat viruses, bacteria, parasites and fungi.” 2011 Amazon
(Cover Photo: TopNews.in)
